Christine P. Hendon develops biomedical optics technologies for biomedicine to guide interventional procedures and to provide insights into the structure-function relationship of biological normal, diseased and treated tissues. She has worked on developing next-generation optical coherence tomography systems and integrated therapeutic catheters with near infrared spectroscopy, along with real-time processing algorithms to extract physiological information. Hendon collaborates extensively with investigators from Columbia University School of Engineering and Applied Science and the Medical Center. Her group has developed integrative optics and therapeutic probes for improving the treatment of cardiac arrhythmias.
Of particular interest to Hendon is the use of optical imaging modalities for improving therapeutic procedures. The research goals of the Structure-Function Imaging Laboratory are to develop platform optical imaging systems to enable structure-function analysis of biological organ systems. Towards this goal, the Lab develops optical coherence tomography (OCT) and near infrared spectroscopy (NIRS) systems and automated processing tools to correlate tissue microstructure to electrical conduction and mechanical contraction. The main clinical driver within this work is addressing unmet needs in cardiac electrophysiology. Hendon works closely with cardiac electrophysiologists, pathologists, and other engineers as they strive to develop catheters and algorithms that will enable improved guidance and monitoring of arrhythmia therapy.